Affiliation:
1. National Cancer Centre
Abstract
Abstract
The incidence of vulvar carcinoma varies by race; however, it is a rare disease, and its genomic profiles remain largely unknown. This study examined the characteristics of vulvar squamous cell carcinoma (VSCC) in Japanese patients, focusing on genomic profiles and potential racial disparities. The study included two Japanese cohorts: the National Cancer Center Hospital (NCCH) cohort comprised 19 patients diagnosed between 2015 and 2023, and the Center for Cancer Genomics and Advanced Therapeutics cohort comprised 29 patients diagnosed between 2019 and 2022. Somatic mutations were identified by targeted or panel sequencing, and TP53 was identified as the most common mutation (52–81%), followed by HRAS (7–26%), CDKN2A (21–24%), and PIK3CA (5–10%). The mutation frequencies, except for TP53, were similar to those of Caucasian cohorts. In the NCCH cohort, 16 patients of HPV-independent tumors were identified by immunohistochemistry and genotyping. Univariate analysis revealed that TP53-mutated patients were associated with a poor prognosis (log-rank test, P = 0.089). Japanese VSCC mutations resembled those of Caucasian vulvar carcinomas, and TP53 mutations predicted prognosis regardless of ethnicity. The present findings suggest potential molecular-targeted therapies for select VSCC patients.
Publisher
Research Square Platform LLC
Reference45 articles.
1. Trends in incidence and long-term survival of Japanese women with vulvar cancer: a population-based analysis;Tanaka Y;Int J Clin Oncol,2019
2. Cancer incidence and mortality patterns among specific Asian and Pacific Islander populations in the U.S;Miller BA;Cancer Causes Control,2008
3. Bucchi, L., Pizzato, M., Rosso, S. & Ferretti, S. New Insights into the Epidemiology of Vulvar Cancer: Systematic Literature Review for an Update of Incidence and Risk Factors. Cancers (Basel). 14 (2022).
4. Geographic and temporal variations in the incidence of vulvar and vaginal cancers;Bray F;Int J Cancer,2020
5. Cancer of the vulva: 2021 update;Olawaiye AB;Int J Gynaecol Obstet,2021