Affiliation:
1. Changzheng Hospital, Naval Medical University (Second Military Medical University
2. Xiang’an Hospital of Xiamen University, Xiamen University
3. Sun Yat-Sen University
4. Changhai Hospital, Naval Medical University (Second Military Medical University
Abstract
Abstract
Renal cancer is a common malignancy of the urinary system, and renal clear cell carcinoma (RCCC) is the most common pathological type. Transmembrane channel-like (TMC) protein is an evolutionarily conserved gene family containing 8 members, however there is still a lack of comprehensive analysis about TMC family members in RCCC. In this study, we analyzed the expression of TMC family members in RCCC from TCGA and investigated the prognosis values and immune infiltration of TMC family members in RCCC. We found that TMC2, TMC3, TMC5, TMC7 and TMC8 were significantly related with overall survival (OS) of RCCC patients. TMC3, TMC6, and TMC8 was positively correlated with the degree of immune infiltration in RCCC. Thus, the TMC family members might be regarded as novel biomarkers for predicting potential prognosis and immunotherapy targets in RCCC patients.
Publisher
Research Square Platform LLC