Convective Dynamics of Swarming Enzymatic Nanomotors

Abstract

Abstract Enzymatic nanomotors harvest kinetic energy through the catalysis of chemical fuels. When a group of self-propelled nanomotors is placed in a fuel-rich environment, they assemble into ordered groups and exhibit intriguing swarming behaviors akin to the self-organization observed in bacterial colonies, bioconvection of aerobic microorganismal suspensions, and the coordinated movements of fish, ants, and birds. This swarming behavior presents numerous advantages compared to individual nanomotors, including expanded coverage and prolonged propulsion duration. However, the physical mechanisms underlying the swarming have yet to be fully elucidated. Our study investigates the formation of enzymatic swarms using experimental analysis and computational modeling. We show that the directional movement of enzymatic nanomotor swarms is due to their solutal buoyancy. We investigated various factors that impact the movement of nanomotor swarms, such as particle concentration, fuel concentration, fuel viscosity, and vertical confinement. We examine the effects of these factors on swarm self-organization to gain a deeper understanding. In addition, the urease catalysis reaction produces ammonia and carbon dioxide, accelerating the directional movement of active swarms in urea compared with passive ones in the same conditions. The numerical analysis agrees with the experimental findings. Our findings are crucial for the potential biomedical applications of enzymatic nanomotor swarms, ranging from enhanced diffusion in bio-fluids and targeted delivery to high- efficiency cancer therapy.