Abstract
Abstract
Background:
Periodontitis (PD) has been linked to low hand grip strength in previous epidemiological observational studies; however, the results are inconclusive. The purpose of this study was to investigate the causal association of PD with hand grip strength.
Methods:
We performed a two-sample bidirectional Mendelian randomization (MR) analysis using publicly released genome-wide association studies (GWAS) statistics. The inverse-variance weighted (IVW) method was used as the primary analysis. We applied three complementary methods, including weighted median, MR-Egger regression and MR pleiotropy residual sum and outlier (MR-PRESSO) to detect and correct for the effect of horizontal pleiotropy. Due to multiple testing, associations with p values < .016 were considered as statistically significant, and p values ≥ .016 and < .05 were considered as suggestively significant. Besides, a multivariable MR (MVMR) design was carried to adjust for body mass index (BMI) and type 2 diabetes (T2D) as well.
Results:
Generally, PD and one of subtypes-Aggressive Periodontitis (AgP) might not affect the risk of low hand grip strength (beta = 0.117 [-0.064, 0.298], beta = -0.018 [-0.042, 0.006]). However, genetically-elevated risk of Chronic Periodontitis (CP) might cause lower hand grip strength (beta = 0.035, p-value = 0.023) while turning insignificant at Bonferroni correction. Besides, no causal effect of hand grip strength on PD and CP was observed (OR = 0.987 [0.964, 1.009]). MVMR analysis also supported such null associations even after adjusting for BMI and T2D.
Conclusion:
This MR study ruled out the causal relationship between PD and hand grip strength, despite observational studies reporting an association between PD and hand grip strength.
Publisher
Research Square Platform LLC