Abstract
Background
Sepsis is a life-threatening organ dysfunction caused by dysregulated host immune response to infection. The relationship between ABO blood type and the occurrence of organ dysfunction the initial stages of sepsis and 28-day mortality has rarely been reported. This study aims to explore the potential association between ABO blood type and the incidence of organ dysfunction and 28-day mortality. This study was a single-center retrospective observational analysis, encompassing all septic patients admitted to our ICU from 2015 to 2021. Various patient characteristics were recorded.
Results
A total of 184 patients diagnosed with sepsis were enrolled in the study, with 166 meeting the specified inclusion criteria. The finding revealed a significant association between d/eOD and ABO blood type. Specifically, individuals with blood type B demonstrated the lowest incidence of d/eOD. Consequently, the septic patients were divided into two groups: blood type B and non-B blood types. Compared to non-B blood types, blood type B exhibited a lower incidence of d/eOD within 7-day (43.40% vs 26.67%, P = 0.03) and 28-day mortality (52.83% vs 26.67%, P < 0.00). Multivariate Cox regression analysis showed that both blood type B [HR 0.42, 95% CI (0.24–0.74), P < 0.01] and SOFA score [HR 1.14, 95% CI (1.05–1.24), P < 0.01] were associated with 28-day mortality. Additionally, blood type B was found to be an independent factor protecting against d/eOD [OR 0.48, 95% CI (0.24–0.96), P = 0.04].
Conclusion
Blood type B has been found to a protective factor in the incidence of d/eOD during early-stage sepsis and 28-day mortality for septic patients.