Abstract
Background
The influence of diurnal variation on anesthetic drug metabolism and effectiveness is established, yet the impact on post-anesthetic extubation and intraoperative cardiac dynamics remains underexplored.
Objective
This investigation seeks to elucidate the impact of general anesthesia induction timing, specifically on extubation timelines and intraoperative vital sign fluctuations during laparoscopic appendectomies.
Methods
Employing a retrospective analysis approach, this study examines extubation timings in patients who underwent laparoscopic appendectomies over a three-year period (2020–2022). Grouping was done based on anesthesia induction timings: a day group (06:00–18:00) and a night group (18:00–06:00). The primary outcome assessed was the variance in extubation times between daytime and nighttime anesthesia inductions. Secondary measures included the frequency of intraoperative complications like hypertension, hypotension, and bradycardia.
Results
Data analysis from 576 laparoscopic appendectomy cases indicated a significant prolongation of extubation times in the night group compared to the day group. Notably, diurnal variations did not significantly affect the incidence of perioperative hypotension, hypertension, or bradycardia.
Conclusion
This study reveals a notable correlation between the diurnal variation and extubation timming in laparoscopic appendectomy patients, suggesting implications for nocturnal anesthesia management. These insights are instrumental in shaping optimal anesthesia protocols for emergency surgical procedures performed at night.