Affiliation:
1. Bushehr University of Medical Sciences
2. Tehran University of Medical Sciences
3. Academy of Human Medicine (Akademie für Menschliche Medizin GmbH)
Abstract
Abstract
Cardiometabolic risk factors increase the chance of developing cardiovascular disease (CVD) and type 2 diabetes. Most CVD risk factors are influenced by total and regional obesity. A higher risk of developing CVD may be linked to vitamin D deficiency, which is more prevalent in the older population. With the goal of evaluating the association between vitamin D and cardiometabolic risk factors and total and regional obesity in older adults, this research included 25 (OH) vitamin D levels and biochemical markers associated with cardiometabolic diseases, as well as total and regional adiposity, which was measured by DXA. A total of 1991 older participants in the PoCOsteo study were included. Overall, 38.6% of participants had vitamin D deficiency. After adjusting for confounders, the results of multiple linear regression suggested an inverse association between vitamin D and body mass index (P = 0.040), waist circumference (P = 0.001), total fat (P = 0.020), android fat (P = 0.001), visceral fat (P < 0.001), subcutaneous fat (P = 0.011), trunk fat (P = 0.006), arm fat (P = 0.037), diastolic blood pressure (P = 0.003), total cholesterol (P < 0.001), LDL-cholesterol (P < 0.001), triglycerides (P < 0.001), and fasting glucose (P < 0.001). Additionally, higher vitamin D levels decreased the risk of dyslipidemia by 2%. Our results showed a significant association between serum vitamin D and a number of cardiometabolic risk factors, including total and regional obesity.
Publisher
Research Square Platform LLC
Reference79 articles.
1. Abdominal obesity and metabolic syndrome;Després JP;Nature,2006
2. Managing cardiometabolic risk in primary care: summary of the 2011 consensus statement;Chatterjee A;Can Fam Physician,2012
3. Brown JC, Gerhardt TE, Kwon E. Risk Factors For Coronary Artery Disease. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2023, StatPearls Publishing LLC.; 2023.
4. Healthy Weight and Obesity Prevention: JACC Health Promotion Series;Lavie CJ;J Am Coll Cardiol,2018
5. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study;Roth GA;J Am Coll Cardiol,2020