Meta-analysis of risk factors for puncture site bleeding after transfemoral artery puncture intervention

Abstract

Abstract Objective To identify the risk factors of bleeding at the puncture site after femoral artery puncture intervention by Meta-analysis, and to provide a basis for postoperative evaluation and prevention of bleeding at the puncture site. Methods China National Knowledge Infrastructure (CNKI), Wanfang, VIP, China Biomedical Literature Service (CBM), PubMed, Medline, The Cochrane Library, EMbase and Web of Science were searched from the establishment of the database to October 10, 2022 Observational studies, including cross-sectional studies, case-control studies, and cohort studies, on risk factors for bleeding at the puncture site after transfemoral artery puncture intervention in the Science database. Newcastle-Ottawa scale (NOS) was used to evaluate the quality of the included studies. Finally, RevMan5.3 software was used for meta-analysis of the literature data. Results Eight articles (total sample size 35250 cases) were included, including 1410 patients in postoperative bleeding group and 33840 patients in non-bleeding group. The influencing factors with statistically significant differences by meta-analysis are as follows: Elderly (OR=2.71, 95%CI = 2.17-3.38), female (R=4.26, 95%CI = 1.08-16.89), hypertension (OR=2.48, 95%CI = 1.69-3.63), obesity (OR=2.33, 95%CI = 1.59-3.42), Thrombolytic agents, anticoagulants, OR platelet antagonists were used (OR=2.95, 95%CI = 2.24-3.89), and manual compression was used (OR=6.78, 95%CI = 1.34-34.43). Conclusions The evidence shows that advanced age, female, hypertension, obesity, the use of thrombolytic agents/anticoagulants/platelet antagonists and manual compression are the risk factors of bleeding at the puncture site after femoral artery puncture intervention, which can provide a reference for the risk assessment of bleeding after clinical surgery and the development of preventive measures.