Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases-Reference-Cited by-同舟云学术

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Published:2023-10-13 Issue: Volume: Page:
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Author:

Huang Jeffrey¹,Shek Naomi¹^ORCID,Choy Anna-Maria¹,Lang Chim¹,Miller Bruce²,Tal-Singer Ruth³,Bolton Charlotte⁴,Thomson Neil⁵,Newby David⁶,Chalmers James¹,Khan Faisel¹,Brown Matthew⁷

Affiliation:

1. University of Dundee

2. COPD Foundation

3. Global Allergy and Airways Patient Platform

4. University of Nottingham

5. University of Glasgow

6. British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science

7. University of Leicester

Abstract

Abstract Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

Publisher

Research Square Platform LLC

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