A Novel Cyclic Voltamnetric Study for the Selective and Sensitive Electroanalytical Determination of Chromium Picolinate in Absence and Presence of Some Reagents in KBr Medium Using Gold Electrode. Application to Commercial Capsules

Abstract

Abstract This study aims to investigate the electrochemical behavior of chromium picolonate (Cr-Pic) in a KBr medium using cyclic voltammetry (CV) with an Au electrode. The determination of Cr-Pic is of great importance due to its potential health benefits and industrial applications. The impact of the presence of various reagents on the electrochemical response of Cr-Pic is also discussed. The study further explores the applicability of the developed method for the analysis of Cr-Pic in commercial capsules. Chromium ions gave a reduction wave above 2.0 V, mainly because of the evolution of gases in the medium. In this work, the catalytic chromium peaks have appeared, affected by the gold electrode. The results were analyzed in the presence or absence of the dye Diamond Fuchsial Basic Violet (1.0 10-2) M in order to assess how the dye and metal ions will interact in solution. We assess the values of the solvation and kinetic parameters (surface coverage, heterogeneous rate constant, diffusion coefficient, and amount of electricity) based on this research. Moreover, the impact of various reactant concentrations, scan rates, and temperatures Different concentrations of Cr-Pic were applied, and the redox peaks were analyzed. Oxidation and reduction waves of Cr-Pic were linearly dependent on its concentration, and calibration curves were linear in the range (0.662–3.23) µM with limits of detection (LOD) (0.215) or (0.053) µM and limits of quantitation (LOQ) (0.654) or (0.163) µM for the gold electrode reduction and oxidation waves, respectively. Adding different concentrations of the dye Diamond Fuchsial Basic Violet (1.0 ×10-2) M to Cr-Pic was necessary, and accordingly, the analysis data is presented in text. The method was successful in the analytical quantification of Cr-Pic in the pharmaceutical capsule. The results were evaluated in comparison with those attained by the comparative approach, and they revealed an acceptable level of agreement. The International Council of Harmonization (ICH) guidelines approved the method to be validated. The effect of Cr-Pic on oxygen waves was also studied, and it was found that a decrease in O2 waves was observed, proving the use of Cr-Pic as a useful antioxidant supplement. Conclusion: Therefore, with minimal risk to people or the environment, the new approach may be employed in the regular quality control investigation of Cr-Pic.