Prevalence of SARS-CoV-2 infection among several populations of primary healthcare workers in comparison to the prediction in the general population and associated factors in France-Reference-Cited by-同舟云学术

Prevalence of SARS-CoV-2 infection among several populations of primary healthcare workers in comparison to the prediction in the general population and associated factors in France

Published:2023-10-19 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Pouquet Marie¹,Decarreaux Dorine²,Domenico Laura Di¹,Sabbatini Chiara E.¹,Prévot-Monsacre Pol¹,Fourié Toscane³,Villarroel Paola Mariela Saba³,Priet Stephane³,Blanché Hélène⁴,Sebaoun Jean-Marc⁴,Deleuze Jean-François⁴,Turbelin Clément¹,Rossignol Louise¹,Werner Andréas⁵,Kochert Fabienne⁵,Grosgogeat Brigitte⁶,Rabiega Pascaline⁷,Laupie Julien⁸,Abraham Nathalie⁷,Noël Harold⁹,Werf Sylvie van der¹⁰,Colizza Vittoria¹,Carrat Fabrice¹,Charrel Remi³,de Lamballerie Xavier³,Blanchon Thierry¹,Falchi Alessandra²

Affiliation:

1. Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP)

2. Université de Corse Pascal Paoli

3. Aix Marseille University, INSERM U1207

4. Fondation Jean Dausset-CEPH

5. Association Française de Pédiatrie Ambulatoire

6. Université Claude Bernard Lyon 1, Université de Lyon

7. IQVIA

8. Réseau ReCOL, Association Dentaire Française

9. Santé publique France

10. Institut Pasteur, Université Paris Cité, CNRS UMR3569

Abstract

Abstract Background Data on the SARS-CoV-2 infection among primary health care workers (PHCWs) are scarce but essential to reflect on policy regarding prevention and control measures. Aim We assessed the prevalence of PHCWs who have been infected by SARS-CoV-2 in comparison with modeling from the general population in metropolitan France, and associated factors. Methods A cross-sectional study was conducted among general practitioners (GPs), pediatricians, dental and pharmacy workers in primary care between May-August 2021. Participants volunteered to provide a dried-blood spot for SARS-CoV-2 antibody assessment and completed a questionnaire. The primary outcome was defined as the detection of infection-induced antibodies or previous self-reported diagnoses. Estimates were adjusted using weights for representativeness and compared with prediction from the general population. Poisson regressions were used to quantify associated factors. Results The analysis included 1612 PHCWs. Weighted prevalences were: 31.7% (95%CI: 27.5-36.0) for GPs, 28.7% (95%CI: 24.4-33.0) for pediatricians, 25.2% (95%CI: 20.6-31.0) for dentists, and 25.5% (95%CI: 18.2-34.0) for pharmacists. Estimates were compatible with model predictions for the general population. PHCWs more likely to be infected were: GPs compared to pharmacist assistants (adjusted prevalence ratio [aPR] = 2.26; CI95% 1.01-5.07), those living in Île-de-France (aPR= 1.53; CI95% 1.14-2.05), South-East (aPR = 1.57; CI95% 1.19-2.08), North-East (aPR= 1.81; CI95% 1.38-2.37), and those having an unprotected contact with a COVID-19 case within the household (aPR = 1.48; CI95% 1.22-1.80). Occupational factors were not associated with infection. Conclusion Results suggest that prevention practices implemented in primary care in France were effective, but should be strengthened when a case is detected at home.

Publisher

Research Square Platform LLC

Reference30 articles.

1. World Health Organization. The impact of COVID-19 on health and care workers: a closer look at deaths. Health Workforce Department – Working Paper 1. Geneva: World Health Organization; September 2021 (WHO/HWF/WorkingPaper/2021.1). Licence: CC BY-NC-SA 3.0 IGO 2021

2. The Lancet. COVID-19: protecting health-care workers. The Lancet. 2020;395(10228):922.10.1016/S0140-6736(20)30644-9

3. Galanis P, Vraka I, Fragkou D, Bilali A, Kaitelidou D. Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: a systematic review and meta-analysis. J Hosp Infect. 2021;108:120 – 34.10.1016/j.jhin.2020.11.008

4. The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis;Kayı İ;Clinical Microbiology and Infection,2021

5. Chen X, Chen Z, Azman AS, Deng X, Sun R, Zhao Z, et al. Serological evidence of human infection with SARS-CoV-2: a systematic review and meta-analysis. The Lancet Global Health. 2021;9(5):e598-e609.10.1016/S2214-109X(21)00026 – 7