LanDis: The Disease Landscape Explorer

Author:

Paccanaro Alberto1,Caniza Horacio2,Cáceres Juan1,Torres Mateo3

Affiliation:

1. Royal Holloway, University of London

2. Universidad Paraguayo Alemana

3. Fundação Getúlio Vargas

Abstract

Abstract From a network medicine perspective, a disease is the consequence of perturbations on the interactome. These perturbations tend to appear in a specific neighbourhood on the interactome, the disease module, and modules related to phenotypically similar diseases tend to be located in close-by regions. We present LanDis, a freely available web-based interactive tool (paccanarolab.org/landis) that allows domain experts, medical doctors and the larger scientific community to graphically navigate the interactome distances between the modules of over 44 million pairs of heritable diseases. The map-like interface provides detailed comparisons between pairs of diseases together with supporting evidence. Every disease in LanDis is linked to relevant entries in OMIM and UniProt, providing a starting point for in-depth analysis and an opportunity for novel insight into the aetiology of diseases as well as differential diagnosis.

Publisher

Research Square Platform LLC

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