Abstract
Plants are a treasure trove of bioactive compounds. One such plant is Kedrostis foetidissima, which belongs to the Cucurbitaceae family. It has very important phytoconstituents like cucurbitacins, rutin, quercetin, and other compounds. These compounds are responsible for various biological activities like anti-microbial, anti-diabetic, anti-cancer, anti-oxidant, anti-anemic, and wound healing properties. Quercetin-3-O- Rhamnoside (1), Rutin (2), 7, 10 - Hexa decadienoic acid methyl ester (3), Docosanoic acid (4), 3,7,11,15-Tetra methyl hexa decan-1-ol (5), and Cucurbitacin-B (6) compounds from this plant were tested for in silico ADMET profiling and drug likeness properties using the Swiss ADME online webserver and the pkCSM server. All the studied compounds are obeying Lipinski's rule of five except compounds 1 and 2, with two and three violations each. The entire selected of compounds has a good bioavailability score in the recommended range of 0 to 1. Compound 4 has high (0.85) and compound 1 and 2 have low (0.17) oral bioavailability scores. All the selected compounds from Kedrostis foetidissima have strong pharmacological activities. Supporting this, the selected plant methanol extracts of leaf, stem callus, and tuber have shown good in vitro antibacterial activity against Bacillus subtilis, Escherishia coli, and Proteus vulgaris.