Clinical Significance of Mean Platelet Volume, Platelet Distribution Width, and Neutrophil-Lymphocyte Ratio in Children with Familial Mediterranean Fever

Abstract

Abstract Background Familial Mediterranean Fever (FMF) is an ethnic and autosomal recessive disorder characterized by recurrent attacks of fever and polyserositis. Recently, several studies have demonstrated the importance of platelet count and volume changes associated with chronic diseases. Mean platelet volume(MPV), platelet distribution width (PDW), and neutrophil/lymphocyte ratio are shown to be essential indicators in many diseases' activation periods. In this study, we aimed to investigate the changes in children with FMF in attacks and attack-free. Materials and Methods In this study, 150 patients had been diagnosed with FMF (90 girls, 60 boys), and 50 healthy subjects (29 male, 21 female) were included. Patients’ data were recorded separately according to under treatment with colchicine, in the attacks and attack-free periods retrospectively. Patients were scored as mild, moderate, and severe. Results MPV levels in patients with FMF were higher than in the healthy group, and MPV levels were significantly lower in attacks than in attack-free periods. This decline was more pronounced with increasing disease severity scores. Conclusion In conclusion, as an easy, inexpensive, and rapid method, MPV measurement is a supportive parameter in determining the severity of the disease and attacks in patients with FMF.