Affiliation:
1. Delta University for Science and Technology
2. Mansoura University
3. University of Suez Canal
Abstract
Abstract
A facile green microwave-assisted method was developed for the production of highly fluorescent nitrogen doped carbon quantum dots (N-CQDs) using sucrose and urea as starting materials. The fluorescent N-CQDs were utilized as nano-sensors for the spectrofluorimetric estimation of furosemide after subjecting to extensive spectroscopic characterization. The quantum yield of the obtained N-CQDs was found to be 0.57. After excitation of the produced N-CQDs at 216 nm, a strong emission band appeared at 376 nm. The fluorescence emission of N-CQDs was quantitatively quenched by adding increased concentrations of the drug. A linear relationship was obtained over the concentration range of 0.1–1.0 µg/mL. The developed method was successfully applied for the estimation of furosemide in its pharmaceutical preparations and biological samples. The mechanism of the quenching was studied and explained. Interference likely to be introduced from co-administered drugs was also studied.
Publisher
Research Square Platform LLC
Reference28 articles.
1. Harvey, R.A. Lippincott`s Illustrated Reviews (5th ed.) 284–285 (Lippincott Williams & Wilkins, 2012).
2. Brayfield, A. Martindale, The Complete Drug Reference (38th ed.) (The Pharmaceutical Press, 2014.
3. The British Pharmacopoeia. British Pharmacopoeia Commission. London (The Stationary Office, 2018).
4. Development of UV spectrophotometric methods and validation for estimation of furosemide in bulk and tablet dosage form by absorbance maxima and area under the curve method;Gahandule M;Int. J. Adv. Pharm.,2016
5. Spectrophotometric determination of furosemide drug in different formulations using Schiff ’s bases;Hassouna MEM;Forensic Res. Criminol. Int. J.,2015