Affiliation:
1. Semnan University of Medical Sciences
Abstract
Abstract
Objectives: To assess and compare the effects of tropicamide 0.5% and tropicamide 1% on intraocular pressure (IOP) and pupil diameter (PD) in patients with diabetes mellitus.
Methods: A total of 98 eyes of 98 diabetic patients were included in this double-masked randomized clinical trial. Patients were randomly assigned to receive either tropicamide 0.5% (49 eyes) or tropicamide 1% (49 eyes). IOP was measured by Goldmann applanation tonometry; PD was measured by Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany), before and 30 min after tropicamide administration.
Results: Mean PD change and IOP change was 2.99 ± 0.62 mm and 0.12 ± 1.71 mm Hg in tropicamide 0.5% group, and was 3.11 ± 0.55 mm and 0.25 ± 1.70 mm Hg in tropicamide 1% group, with no significant difference (P = 0.31, P = 0.72, respectively). No participants had IOP increase of 5 mm Hg or more.
Conclusion: The effect of tropicamide 0.5% and tropicamide 1% drops on IOP and PD was similar. Mydriasis with tropicamide did not result in significant IOP change.
Publisher
Research Square Platform LLC
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