Association Between Remnant Cholesterol and Risk of Asthma: NHANES 2005 - 2018

Abstract

Abstract Introduction Remnant cholesterol is an important lipid substance that plays multiple physiological functions in the human body. It plays multiple physiological functions in the human body. Asthma is a common and widespread disease that affects chronic respiratory disease in the global population. In this study, we paid special attention to whether remnant cholesterol was associated with asthma. Methods Residual cholesterol levels were divided into continuous and binary variables as exposure variables and asthma as outcome variable. Other covariables are considered potential confounders that may act as effect modulators. Using seven combined circles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, this cross-sectional study sought a clear association between exposure and outcome through multiple regression models, subgroup analysis, and smoothed curve fitting tests. Results In the multivariable logistic regression analyses, a negative association was discovered between remnant cholesterol levels and the risk of asthma, with all confounders adjusted except smoking status and COPD. In subgroup analyses stratified by COPD, smoking status, and gender, never-smoking and COPD patients followed a U-shaped curve, andfemales followed a positive association, which was revealed intuitively by smooth fitting curves. Conclusions Remnant cholesterol levels are inversely associated with the development of asthma. However, the association between remaining cholesterol levels and asthma events in never-smoking and COPD patients followed a U-shaped curve, with females following a positive association.