Questionnaire survey of Healthcare Professionals on Taxane-Induced Nail Change in Japan

Abstract

Abstract Purpose: Taxanes are widely used chemotherapeutic agents that frequently cause nail changes and have a significant impact on patients’ quality of life. Despite the prevalence of taxane-induced nail toxicity, limited data are available regarding evidence-based management strategies for the prevention or treatment of taxane-induced nail changes. Therefore, we aimed to disseminate a questionnaire survey to physicians, pharmacists, and nurses involved in oncology treatment to gain accurate insights into the prevention, treatment, and evaluation of nail changes in patients with cancer in Japan. Methods: Questions addressed prophylactic methods, evaluation practices, and treatment approaches for various nail disorders. Questionnaires were distributed on March 1, 2022, with a response deadline of December 1, 2022. Results: Of the 120 distributed questionnaires, 88 (73.3%) responses were deemed valid. The respondents included 69 physicians (32 oncologists, 26 breast surgeons, 6 dermatologists, 3 obstetricians/gynecologists, 1 gastroenterological surgeon, and 1 urologist), 9 pharmacists, and 10 nurses. Prophylactic measures included moisturizing (58.0%), protection (42.0%), cooling therapy (37.5%), and cleanliness (33.0%). Approximately 70% of the respondents used the Common Criteria for Adverse Events (CTCAE), while approximately 30% did not use a specific evaluation method. Opinions regarding treatment with antimicrobial or corticosteroid ointments varied; however, all severe cases were referred by dermatologists. Conclusion: This survey revealed that the management of chemotherapy-induced nail changes varies in clinical practice in Japan. These findings emphasize the need for standardized management strategies and further research.