A synergistic effect of fibrous carboxymethyl cellulose with equine collagen improved the hemostatic properties of freeze-dried wound dressings

Author:

Sedlář Marian1,Kacvinská Katarína1,Fohlerová Zdenka2,Izsák David1,Chalupová Marta3,Suchý Pavel3,Dohnalová Marcela4,Sopuch Tomáš5,Vojtová Lucy1

Affiliation:

1. Central European Institute of Technology, Brno University of Technology

2. Department of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology

3. Department Pharmacology and Toxicology, Faculty of Pharmacy, Masaryk University

4. Collado s.r.o

5. Holzbecher, spol. s r. o., barevna a bělidlo Zlíč

Abstract

Abstract Bleeding is one of the most commonly occurring injuries; it can be painful and even life-threatening condition. The hemostats are substances that promote blood clotting and fasten hemostasis. In this paper, we evaluated the hemostatic effect of freeze-dried wound dressings based on equine collagen, porcine collagen, fibrous carboxymethyl cellulose (CMC) and their mixtures. The wound dressings were investigated for their morphological structure, chemical structure, absorption properties, in vitro hemostasis, cytotoxicity assay and lastly, for in vivo hemostasis. We have found out that adding fibrous CMC into collagen-based hemostatic wound dressings creates a strong synergistic effect, which significantly improves absorption capacity by almost doubling it, as well as supports clotting time. Based on the in vivo studies on partial nephrectomy in rats, the time needed for achieving hemostasis was significantly lower due to the synergy of collagen and CMC. Our materials were compared to the commonly used hemostatic sealing patch on the market (Tachosil) during the in vivo testing, and sample of a mixture of equine collagen and CMC showed better hemostatic efficacy.

Publisher

Research Square Platform LLC

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