Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China

Author:

Wu Joseph T1,Leung Kathy1,Bushman Mary2,Kishore Nishant2,Niehus Rene2,Salazar Pablo M de2,Cowling Benjamin J1,Lipsitch Marc2,Leung Gabriel M1

Affiliation:

1. WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong

2. Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health

Abstract

Abstract As of February 13, 2020, there have been 59,863 laboratory-confirmed cases of COVID-19 infections in mainland China, including 1,367 deaths. A key public health priority during the emergence of a novel pathogen is estimating clinical severity. Here we estimated the symptomatic case-fatality risk (sCFR; the probability of dying from the infection after developing symptoms) of COVID-19 in Wuhan using public and published information. We estimated that sCFR was 0.5% (0.1%-1.3%), 0.5% (0.2%-1.1%) and 2.7% (1.5%-4.7%) for those aged 15-44, 45-64 and >64 years. The overall sCFR among those aged ≥15 years was 1.4% (0.8%-2.0%). Authors Joseph T Wu and Kathy Leung contributed equally to this work

Publisher

Research Square Platform LLC

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