Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study

Abstract

Abstract Background: Uric acid (UA), a liver-derived metabolite, is intimately tied to metabolic disorders. Although ample research underscores its connection with hypertriglyceridemia (HTG), studies focusing on adolescents remain limited. This investigation delves into the correlation between uric acid levels and HTG among American adolescents. Methods: This cross-sectional study utilized data on 4,435 adolescents from the NHANES database spanning 2011 to 2020. The exposure variable was serum uric acid (SUA), the outcome variable was HTG, and the covariates encompassed demographics, questionnaire, physical examination and laboratory indicators. We utilized weighted logistic regression and meticulous subgroup evaluations to discern the intrinsic link between SUA and HTG. Stratified analyses augmented the validation of this association, while smooth curve fitting probed for potential non-linear correlations. Results: The study included 4,435 participants. Male adolescents might exhibit elevated SUA levels. After adjusting for all variables, the weighted multiple logistic regression model revealed that SUA had a positive correlation with HTG risk. This relationship was consistent across tertiles. Stratified analyses confirmed that the positive correlation between SUA and HTG risk was significant, irrespective of sex, age and race. Conclusions: In American children and adolescents aged 12 to 18 years, there's a pronounced affiliation between SUA and HTG. SUA could serve as a risk indicator for HTG. Regular monitoring of serum triglycerides is recommended to prevent HTG during childhood.