High standard uptake value on FDG-PET/CT of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection

Author:

Kato Kazuya1,Noda Takehiro1,Kobayashi Shogo1,Yamanaka Chihiro1,Sasaki Kazuki1,Iwagami Yoshifumi1,Yamada Daisaku1,Tomimaru Yoshito1,Takahashi Hidenori1,Asaoka Tadafumi1,Shimizu Junzo1,Doki Yuichiro1,Eguchi Hidetoshi1

Affiliation:

1. Osaka University

Abstract

Abstract Purpose Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful for detecting the presence of distant metastases in many types of cancer, including hepatocellular carcinoma (HCC). However, the clinical significance of the standard uptake value (SUV) in primary HCC lesions is unclear. Therefore, we investigated the relationship between the SUV, clinicopathological factors, and prognosis in HCC. Methods The retrospective analysis included 86 patients with HCC who underwent FDG-PET/CT prior to liver resection. The distribution of SUV was compared in three groups: no recurrence after surgery, recurrence within 2 years, and recurrence after 2 years. The optimal cut-off SUV were determined based on receiver operating characteristic curve analysis to detect the recurrence within 2 years. All patients were divided into two groups based on the cut-off: low and high SUV. Cox univariate and multivariate analyses were performed for disease-free survival. Results The SUV was significantly higher in patients with recurrence within 2 years. The optimal cut-off SUV was 5.0. The patients in the high SUV group had significantly higher des-γ-carboxy prothrombin, poorer differentiation, and larger tumor diameter than the low SUV group, and presented with pathologically positive intrahepatic metastases. Moreover, high SUV was a significant and independent prognostic factor. In a subgroup analysis, high SUV had a significantly lower 2-year disease-free survival rate than the low SUV group in tumors ≤ 3.5 cm. Conclusion High SUV (≥ 5) on FDG-PET/CT of the primary HCC lesion, especially tumors ≤ 3.5 cm, correlates with early recurrence after curative resection and is an independent prognostic factor.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3