Garcidepsidon B from Garcinia parvifolia: Antimicrobial Activities of The Medicinal Plants from North Kalimantan against Dental Caries and Periodontal Disease Pathogen

Abstract

Abstract In this study, to find the potential of antibacterial materials, we focused on the plant used for oral treatment by native people of North Kalimantan. We have selected 10 medicinal plants usually used in daily life by native people. We determine samples using antimicrobial assay and Gtase Inhibitory activity. We obtained the most effective sample, Garcinia parvifolia, as antimicrobial activity against the Streptococcus sobrinus and Porphyromonas gingivaliswith a MIC value of 0.5 mg/ml inhibition on both of bacteria and MBC value of 0.5 mg/ml and 1 mg/ml, respectively. The methanol extract of G. parvifolia leaf showed antimicrobial activity in a MIC, and MBC assay by activity-guide fractionation, garcidepsidone B (1) was isolated as an active com-pound. The MIC of (1) against S. sobrinus was 0.02 mg/mL and against P. gingivalis was 0.05 mg/mL. Based on these results, we validated that the leaf extract has been used by the traditional tribe of North Kalimantan.