Association of dietary and serum selenium with heart failure among the adults: NHANES 2011-2018

Abstract

Abstract Background and Aims: The relationships of dietary and serum selenium level and the risk of heart failure (HF) were controversial. The purpose of this study was to examine the associations of dietary and serum selenium level with the risk of HF in a large sample of American adults. Methods: The relationships of dietary and serum selenium level and the risk of HF were analyzed in a sample of 13323 adults from the 2011–2018 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression and restricted cubic spline models were applied to analyze the correlation of dietary and serum selenium level with HF. Subgroup analyses based on age and sex were performed. Results:In multiple regression model, we found that dietary and serum selenium were both inversely associated with HF risk. Compared with subjects in the lowest quartile (Q1), those with dietary selenium intake in Quartile 4 demonstrated OR (95%CI) for HF risk of 0.64 (0.40-0.98), and those with serum selenium concentration in Quartile 3 and Quartile 4 indicated ORs (95%CIs) for HF risk of 0.61 (0.41-0.91) and 0.51 (0.33-0.78) in Model 2. Dietary selenium had correlation with HF in both male and female, and serum selenium was inversely associated with HF in male, but not in female. Then the negative relationship of dietary and serum selenium with HF was particularly pronounced among participants aged ≥60. In the results of dose–response analysis, a linear relationship was found of dietary and serum selenium with the risk of HF respectively. Conclusion: Our study summarized that dietary and serum selenium were both inversely associated with the risk of HF in American adults, and the correlations were linear.