Potential dynamic corneal response parameters for myopia: Relationship of axial length with whole eye movement at the first and second applanations and the highest concavity

Abstract

Abstract Purpose: To investigate the correlation between whole eye movement (WEM) parameters measured using Corvis ST and axial length (AL) to explore whether AL has an effect on WEM in addition to orbital soft tissue. Methods: This single-center, cross-sectional study included data from healthy subjects and patients preparing for refractive surgery in the Qingdao Eye Hospital of Shandong First Medical University. Data were collected from July 2021 to April 2022. First, we determined the correlations of WEMs at the time of first applanation (A1_WEM), highest concavity (HC_WEM) and second applanation (A2_WEM) and the maximum value of WEM (WEM_Max) with AL. Then we established a series of regression models to analyze the relationship between different WEM values and AL. Results: AL was negatively correlated with HC_WEM, A2_WEM, and WEM_Max (r = −0.28, −0.23, and −0.22, respectively; P < 0.001). The correlation between AL and A1_WEM was not significant (P = 0.77). In adjusted regression models, AL was negatively associated with HC_WEM (Model 2: β = −7.39, P < 0.001) and WEM_Max (Model 4: β= −3.52, P = 0.02), but the associations of AL with A1_WEM (Model 1: P= 0.61) and A2_WEM (Model 3: P = 0.23) were not significant. Conclusions: This study confirmed a negative correlation between AL and HC_WEM. AL is an independent influencing factor for HC_WEM.