Association analysis of the Ex3 VNTR polymorphism of the DRD4 dopamine receptor gene with personality traits in patients with a behavioural addiction-Reference-Cited by-同舟云学术

Association analysis of the Ex3 VNTR polymorphism of the DRD4 dopamine receptor gene with personality traits in patients with a behavioural addiction

Published:2024-06-11 Issue: Volume: Page:
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Author:

Boroń Agnieszka¹,Recław Remigiusz¹,Chmielowiec Krzysztof²,Chmielowiec Jolanta²,Strońska-Pluta Aleksandra¹,Kowalski Michał Tomasz³,Masiak Jolanta⁴,Gibas-Dorna Magdalena⁵,Trybek Grzegorz¹,Grzy-wacz Anna¹

Affiliation:

1. Pomeranian Medical University in Szczecin

2. University of Zielona Góra

3. Nowa Sól Multidisciplinary Hospital

4. Medical University of Lublin

5. University of Zielona Gora

Abstract

Results In behavioural and amphetamine addicts with a higher level of the STAI trait scale and a higher level of the Neuroticism scale, the DRD4 Ex3 s/s gene polymorphism occurred significantly more often compared to the control group with the s/s polymorphism and the l/l and s/l polymorphism. Similarly, in people addicted to behavioural and amphetamine with a higher level of the STAI trait scale and a higher level of the Neuroticism scale, the DRD4 Ex3 s/l gene polymorphism occurred significantly more frequently compared to the control group with the s/s polymorphism. Conclusions: In the presented study, we see that ad-dictions should be analysed multifactorial. We can conclude that DRD4 and its polymorphic variant influence addiction development.

Publisher

Research Square Platform LLC

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