Predictive Characteristics and Model Development for Acute Heart Failure Preceding Hip Fracture Surgery in Elderly Hypertensive Patients: A Retrospective Machine Learning Approach

Abstract

Abstract Background: Hip fractures are a serious health concern among the elderly, particularly in patients with hypertension, where the incidence of acute heart failure preoperatively is high, significantly affecting surgical outcomes and prognosis. This study aims to assess the risk of preoperative acute heart failure in elderly patients with hypertension and hip fractures by constructing a predictive model using machine learning on potential risk factors. Methods: A retrospective study design was employed, collecting preoperative data from January 2018 to December 2019 of elderly hypertensive patients with hip fractures at the Third Hospital of Hebei Medical University. Using SPSS 24.0 and R software, predictive models were established through LASSO regression and multivariable logistic regression analysis. The models' predictive performance was evaluated using metrics such as the concordance index (C-index), receiver operating characteristic curve (ROC curve), and decision curve analysis (DCA), providing insights into the nomogram's predictive accuracy and clinical utility. Results: Out of 1038 patients screened, factors such as gender, age, history of stroke, arrhythmias, anemia, and complications were identified as independent risk factors for preoperative acute heart failure in the study population. Notable predictors included Sex (OR 0.463, 95% CI 0.299-0.7184, P=0.001), Age (OR 1.737, 95% CI 1.213-2.488, P=0.003), Stroke (OR 1.627, 95% CI 1.137-2.327, P=0.008), Arrhythmia (OR 2.727, 95% CI 1.490-4.990, P=0.001), Complications (OR 2.733, 95% CI 1.850-4.036, P＜0.001), and Anemia (OR 3.258, 95% CI 2.180-4.867, P＜0.001). The model's AUC was 0.785 (95% CI, 0.754–0.815), and decision curve analysis (DCA) confirmed the nomogram's excellent performance in predicting the incidence of preoperative acute heart failure in elderly patients with hypertension and hip fractures. Conclusion: The predictive model developed in this study is highly accurate and serves as a powerful tool for the clinical assessment of the risk of preoperative acute heart failure in elderly hypertensive patients with hip fractures, aiding in the optimization of preoperative risk assessment and patient management.