Analysis of risk factors related to assisted reproduction and assisted pregnancy outcomes in infertile men

Abstract

Abstract Objective This study investigated the risk factors of assisted pregnancy outcomes in infertile men receiving assisted reproductive treatment and established a risk prediction model. Methods A cross-sectional survey was conducted on 1037 infertile men who underwent ICSI-ET assisted pregnancy at the Reproductive Medicine Center of Obstetrics and Gynecology Hospital Affiliated to Tongji University from March 2023 to September 2023, and the clinical information of 403 gestation cycles (study group) and 634 non-gestation cycles (control group) were compared. Logistic regression was used to analyze the risk factors of assisted pregnancy outcomes in infertile men. The R software was used to draw the histogram and receiver operating characteristics (ROC) curve. Results Single factor results showed that there were differences between the two groups in age, BMI, smoking, drinking, drinking tea, daily sleep time, daily exercise time, anxiety, depression, stress, insomnia, forward motile sperm rate, inactive sperm rate, sperm DNA fragmentation index, sperm survival rate, chlamydia infection and other 16 factors (P < 0.05). Multivariate regression showed that age, BMI, smoking, drinking, daily sleep time, daily exercise time, anxiety, depression, insomnia, forward motility sperm rate, sperm DNA fragmentation index and sperm survival rate were independent risk factors for assisted pregnancy outcome of infertile men (P < 0.05). The nomogram and the area under ROC curve show that the risk prediction model has good performance. Conclusion The assisted pregnancy outcome of male infertile patients is affected by many factors, and the medical staff can make a predictive plan according to the predicted results.