Abstract
Background
Mendelian randomization method was used to explore the causal relationship between the occurrence of arthritis disease and volume changes in specific cerebral cortical regions.
Methods
By analyzing the GWAS summary data,SNP data related to arthritis and cerebral cortex volume were selected.Using the inverse variance weighted (IVW) method as the preferred method, MR Egger, Simple Mode, Weighted Median, and Weighted Mode were used as auxiliary analysis to conduct a two-sample bidirectional Mendelian randomization analysis.
Result
IVW analysis showed that Arthrosis was positively correlated with the volume of Left Crus I Cerebellum (OR = 1.18, 95%CI: 1.09 ~ 1.28, P = 9×10− 5).Gout was negatively correlated with the volume of Left Frontal Operculum Cortex (OR = 0.97, 95% CI: 0.95 ~ 0.98, P = 5×10− 5).Gout was positively correlated with Left Precentral Gyrus volume (OR = 1.05, 95%CI: 1.04 ~ 1.07, P = 1.9×10− 11).No positive results were obtained by reverse MR analysis.
Conclusion
Arthrosis promotes increased volume of the Left Crus I Cerebellum.Gout promotes decreased volume of the Left Frontal Operculum Cortex.Gout promotes increased volume of the Left Precentral Gyrus.