Physical activity in liver transplant recipients: a large multicenter study

Author:

Gitto Stefano1ORCID,Golfieri Lucia2,Gabrielli Filippo3,Falcini Margherita4,Sofi Francesco4,Tamè Maria Rosa2,De Maria Nicola5,Marzi Luca6,Mega Andrea6,Valente Giovanna7,Borghi Alberto8,Forte Paolo4,Cescon Matteo2,Benedetto Fabrizio Di9,Andreone Pietro3,Petranelli Marco10,Morelli Maria Cristina2,De Simone Paolo11,Lau Chloe12,Stefani Laura13,Vizzutti Francesco13,Chiesi Francesca13,Marra Fabio13,GROUP MEDITRA RESEARCH13

Affiliation:

1. University of Florence: Universita degli Studi di Firenze

2. Universita degli Studi di Bologna Azienda Ospedaliera di Bologna Policlinico S Orsola-Malpighi: IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico di Sant'Orsola

3. Azienda Ospedaliero-Universitaria di Modena Ospedale Civile di Baggiovara

4. AOU Careggi: Azienda Ospedaliero Universitaria Careggi

5. Policlinic of Modena: Policlinico di Modena

6. Bolzano Hospital: Ospedale di Bolzano

7. Azienda Sanitaria Locale Caserta

8. Faenza Hospital: Ospedale degli Infermi di Faenza

9. Policlinico di Modena

10. Università degli Studi di Firenze: Universita degli Studi di Firenze

11. Pisana University Hospital: Azienda Ospedaliero Universitaria Pisana

12. University of Western Ontario Faculty of Science: Western University Faculty of Science

13. Universita degli Studi di Firenze

Abstract

Abstract Aim Healthy lifestyle and appropriate diet are of critical importance after liver transplant (LT). The present study was undertaken to analyse the impact of physical activity in a large cohort of LT recipients. Methods Clinically stable LT recipients were enrolled between June and September 2021. Patients completed a composite questionnaire about physical activity, adherence to Mediterranean Diet (MD), quality of life (QoL), and employment. Correlations were analysed using the Pearson coefficients while different subgroups were compared by t-test for independent samples or ANOVAs. Multivariable logistic regression analysis was conducted to find predictors of inactivity. Results We enrolled 511 subjects (71% males, mean age 63 ± 10.8 yrs). One hundred and ninety-three patients reported high level of physical activity, 197 a minimal activity and 121 declared insufficient activity. Among these latter, 29 subjects were totally inactive. Considering the 482 LT recipients performing some kind of physical activity, almost all reported a low-quality, non-structured activity. At multivariate analysis, time from LT (odds ratio 0.94, 95% CI 0.89–0.99, p = 0.017), sedentary lifestyle (odds ratio 0.99, 95% CI 0.19–0.81, p = 0.012), low adherence to MD (odds ratio 1.22, 95% CI 1.01–1.48, p = 0.049), and low level of QoL (physical dimension) (odds ratio 1.13, 95% CI 1.08–1.17, p < 0.001), were independently associated with total inactivity. Conclusions A large portion of LT recipients report an insufficient level of physical activity or are wholly inactive. Inactivity increases with time from LT, and was strongly associated with suboptimal diet and low QoL.

Publisher

Research Square Platform LLC

Reference49 articles.

1. European Association for the Study of the Liver (2016) EASL Clinical Practice Guidelines: Liver transplantation. J Hepatol 64:433–485. https://doi.org/10.1016/j.jhep.2015.10.006. Electronic address: easloffice@easloffice.eu

2. Physical Activity in Liver Transplantation: A Patient’s and Physicians’ Experience;Beekman L;Adv Ther,2018

3. Exercise and physical activity for patients with end-stage liver disease: Improving functional status and sarcopenia while on the transplant waiting list;Duarte-Rojo A;Liver Transpl,2018

4. Improved physical performance after orthotopic liver transplantation;Beyer N;Liver Transpl Surg,1999

5. A randomized trial of exercise and dietary counseling after liver transplantation;Krasnoff JB;Am J Transplant,2006

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