Effects of lipoprotein(a) in aortic dissection patients and acute myocardial infarction patients with chest pain: A Cross-sectional Study

Abstract

Abstract Background: Aortic dissection patients entering the hospital may suffer from chest pain and have a deviation value of lipoprotein(a) (Lp(a)). In the present study, we aimed to investigate the clinical importance of Lp(a) level among aortic dissection(AD) patients, healthy control , and acute myocardial infarction(AMI) patients.Method: Acute AD patients (n=257), AMI patients (n=99) and healthy subjects (n=99) were enrolled into our research. We measured Lp(a) level at the admission. We recorded the baseline demographic data and laboratory outcomes. The endpoint was death situation in patients during one month. Then we performed statistical analysis to determine the association between lp(a) level and diseases. Student’s t-test analysis and multiple logistic regression were used to identify lp(a) level difference among groups Results: Researchers interviewed a total of 257 patients with AAD. AAD patients had higher Lp(a) level than healthy control(165(91,301.5) vs.136(68,222).p＜0.001) and lower Lp(a) level than AMI patients(165(91,301.5) vs.231(123,386).p＜0.001). In one month follow-up, the survivors have a higher Lp(a) level than the death toll. Univariate regression analysis showed that Lp(a) was a significant indicator of aortic dissection(OR 1.001, 95% Cl 1.000-1.003, p=0.039). However, after adjusted for other risk factors, an increased risk of having AAD is not observed for a high level of Lp(a)(OR,1.001;95% Cl 0.999-1.003, p=0.4).Conclusions: Serum lipoprotein(a) levels were significantly higher in AAD patients than healthy control. Moreover, the high lp(a) level was found to be independently associated with a better prognosis of AAD. Higher lipoprotein(a) may enhance vessel atherosclerosis, accelerate thrombosis process and promote inflammation response by avoiding the formation of aortic dissection.