Correlation analysis of PPP2R1A gene expression and immune infiltration in hepatocellular carcinoma

Abstract

Abstract Background To investigate the effect and prognostic value of PPP2R1A on immune infiltration in hepatocellular carcinoma (HCC). Methods The expression of PPP2R1A in HCC and its relationship with the prognosis of HCC patients were analysis by The Cancer Genome Atlas (TCGA) database using bioinformatics methods and verified by immunohistochemical staining. Immunomodulators associated with PPP2R1A were extracted from the TISIDB database, and immune events associated with PPP2R1A were analysis by KEGG pathway enrichment. COX regression was used to develop a multigene risk prediction model for prognostic risk model construction and validation. Results The expression level of PPP2R1A in hepatocellular carcinoma tissues was significantly higher than that in paraneoplastic tissues (P < 0.05).The overall survival of the PPP2R1A high expression group was significantly lower than that of the low expression group (P = 0.003). The risk score can be used as an independent predictor of prognosis in patients with hepatocellular carcinoma. Conclusion PPP2R1A is highly expressed in hepatocellular carcinoma, and its expression level correlates with the overall survival of patients; PPP2R1A correlates with the tumor immune infiltration of hepatocellular carcinoma, suggesting that PPP2R1A may be a potential immunotherapeutic target for hepatocellular carcinoma.