Adult genitourinary sarcoma: Analysis using hospital-based cancer registry data in Japan

Abstract

Abstract Objectives We aimed to elucidate the clinical characteristics, survival outcomes and prognostic factors for overall survival of adult genitourinary sarcoma in Japan.Methods A hospital-based cancer registry data in Japan was used to identify and enroll patients diagnosed with genitourinary sarcoma in 2013. The datasets were registered from 121 institutions.Results A total of 116 men and 39 women were included, with a median age of 66 years. The most common primary site was the kidney in 47 patients, followed by the paratestis in 36 patients. The most common histological type was liposarcoma in 54 patients, followed by leiomyosarcoma in 25 patients. The 5-year overall survival rates were 57.6%. On univariate analysis, male gender, primary organ of paratestis, histological subtype of liposarcoma, and treatment with surgery were predictive of favorable survival while primary kidney, bladder or prostate gland, and treatment with chemotherapy or radiation were predictive of unfavorable survival. On multivariate analysis, primary paratestis and treatment with surgery were independent predictors of favorable survival while treatment with chemotherapy was an independent predictor of unfavorable survival.Conclusions We revealed clinical characteristics and survival outcomes of adult genitourinary sarcoma in Japan using a real-world large cohort database. Primary paratestis and treatment with surgery or chemotherapy were independent, significant factors for prognosis.