Classification of central nervous system tumors histological diagnosed in a single center of Northwest China 2003-2019

Abstract

Abstract Background: The classification of the central nervous system (CNS) tumors has changed greatly. The Central Brain Tumor Registry of the United States (CBTRUS) and other institutions have conducted analyses on the new cases of primary CNS tumors. However, there are limited studies analyzing the incidence rate and characteristics of CNS tumors reported in China. To better understand the CNS tumors in China, we summarized the case details of all CNS primary tumors diagnosed pathologically in a single center from 2003 to 2019. Methods: All patients with CNS tumors who underwent neurosurgery at our Hospital from Jan 2003 to Dec 2019 were included in the study. The information of all patients was collected from the hospital information system, including diagnosis time, age, gender, anatomical sites, pathological results, etc. Results: A total of 17,226 cases of primary CNS tumors were retrospectively analyzed in this study. Among all cases screened, the major tumor types included meningiomas, tumors of neuroepithelial tissue, and pituicytomas. The majority of tumors of neuroepithelial tissue were glioblastoma and astrocytoma. Most tumors of neuroepithelial tissue are located in the frontal lobe. Further, the proportion of the frontal lobe increased with the grade. The median age of all patients was 46 years. The incidence of CNS tumors is higher in women than in men. Conclusions: Based on this data set, we analyzed various parameters including the types, biological properties, and anatomical site of CNS tumors as well as patients’ age, gender, and race, and provided researchers and clinicians with information on the incidence rate of CNS tumors.