Effect of Lactobacillus brevis (MG000874) on Antioxidant Related Genes Expression of liver and kidney in d-galactose Induced Oxidative stress Mice Model”

Abstract

Abstract Oxidative stress connected with several stress-associated diseases. Potent radical-scavenging activity of Latic acid bacteria had been stated due to its ridiculous antioxidant activity. This work designed to find the defensive effects of Lactobacillus brevisMG000874 against oxidative injuries induce by d-galactose in vivo and as well as to explore the gene expression changes in oxidative stress induce mice. D-galactose (D-gal) induction (300mg/BW) in mice raised the levels of SOD (superoxide dismutase) and CAT (catalase) determined by spectrophotometer. In addition, Lactobacillus brevis MG000874 altered gene expression of oxidative stress marker at the messenger RNA (mRNA) levels was determined by RT-PCR. In the mouse model, L. brevis MG000874 significantly improved the GST, GPX, SOD, CAT and B-actin levels in kidney, and liver of the D-gal-induced mice. Moreover, the histological investigation indicated that Lactobacillus brevis MG000874 effectively relieved kidney and liver damage in mice induced by D-gal. L. brevis MG000874 as a powerful antioxidant mediator endorsed fitness and lessened the risk of stress-linked diseases.