Abstract
The present research work was carried out to evaluate efficacy of moxifloxacin and marbofloxacin in clinical mastitis in buffaloes. Total 20 clinical mastitis positive buffaloes were selected after screening of 129 lactating buffaloes by strip cup test and clinical signs, in and around Parbhani area. The selected buffaloes were divided into 2 groups, 10 animals in each. Group I was treated with Inj. Moxifloxacin @ 5 mg/kg BW IM for 5 days and group II received Inj. Marbofloxacin @ 2 mg/kg BW IM for 5 days. Supportive treatment was given in both groups as antihistaminic, multivitamins and NSAIDs. The clinical parameters like rectal temperature, heart rate and respiratory rate showed significant improvement in both the treatment groups. Haematolgical studies showed significant improvement in TLC, neutrophil and lymphocyte count while apparent but non-significant improvement observed in Hb, PCV, basophil, eosinophil and monocyte count. On bacterial isolation, most frequent bacteria observed were Staphylococcus aureus (48.14%), followed by E. coli (25.92%), Klesiella spp. (14.81%) and mixed bacterial infection (11.11%). Results of antibiotic sensitivity test of samples showed sensitive to, in descending order, Marbofloxacin (70%), Moxifloxacin (50%), Enrofloxacin (60%) and Ciprofloxacin (50%). Efficacy of marbofloxacin @ 2 mg/kg BW IM for 5 days was more (70%) compared to moxifloxacin @ 5 mg/kg BW IM for 5 days (50%). Hence, marbofloxacin was found more effective than moxifloxacin for treatment and control of mastitis in buffalo.