Causal Relationship Between Cystatin C and Herpes zoster: A Mendelian Randomization Analysis

Abstract

Abstract Objective This study aimed to examine the association between cysteine ​​C and Herpes zoster (HZ). Method We acquired data from the MR Base database and used Mendelian randomization (MR) to evaluate the causal association between cysteine ​​C and HZ. Results We selected five single nucleotide polymorphisms from genome-wide association studies that were significantly associated with both cysteine ​​C and HZ. Inverse weighted variance (IVW) and weighted median methods showed that MCI had a protective effect on CP (IVW: β=-1.229, P = 0.010, odds ratio [OR] = 0.293, 95% confidence interval [CI] = 0.114–0.749; Weighted median: β=-1.328, P = 0.008, OR = 0.265, 95%CI = 0.100-0.705). However, MR-Egger analysis suggested no causal association (β=-1.642, P = 0.103, OR = 0.194, 95%CI = 0.048–0.774). The greater precision of weighted median estimator and IVW suggest our results may support a potential causal association between cysteine ​​C and HZ . Conclusion The MR analysis demonstrated that cysteine ​​C has a protective effect on HZ.