Affiliation:
1. Fukushima Medical University Aizu Medical Center
2. Fukushima Medical University School of Health Sciences
3. Fukushima Medical University School of Medicine
4. Fukushima Medical University
Abstract
Abstract
The Great East Japan Earthquake occurred in Japan on March 11, 2011, with a nuclear accident occurring at the Fukushima Daiichi Nuclear Power Plant afterward. The disaster constrained many evacuees to change their lifestyles. However, the effect of evacuation on the new-onset of hyperuricemia have not been sufficiently elucidated. We aimed to assess the association between evacuation and new-onset hyperuricemia after the earthquake based on the Fukushima Health Management Survey from a lifestyle and socio-psychological perspective. A longitudinal study examined data collected from 18,140 residents (6,961 men and 11,179 women) with non-hyperuricemia who underwent both the Comprehensive Health Check and the Mental Health and Lifestyle Survey between 2011 and 2017. Using a Cox proportional hazards regression model analysis, we estimated associations between new-onset hyperuricemia and lifestyle- and disaster-related factors, including evacuation. We defined hyperuricemia as uric acid levels > 7.0 mg/dL for men and > 6.0 mg/dL for women. A total of 2,996 participants (1,608 men, 23.1%, 1,388 women, 12.4%) newly developed hyperuricemia during a median follow-up of 4.3 years. This study observed significant associations between evacuation and onset of hyperuricemia in women (adjusted hazard ratio 1.18, 95% confidence interval, 1.05–1.32, p = 0.007), but not in men (adjusted hazard ratio 1.11, 95% confidence interval, 0.99–1.24, p = 0.067). Evacuation after a natural disaster is an independent risk factor for the new-onset of hyperuricemia in women.
Publisher
Research Square Platform LLC