MRPL27 as a new prognostic biomarker involved in immune cell infiltration and hepatocellular carcinoma progression-Reference-Cited by-同舟云学术

MRPL27 as a new prognostic biomarker involved in immune cell infiltration and hepatocellular carcinoma progression

Published:2024-05-30 Issue: Volume: Page:
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Author:

Yang JiaYing¹,Lin Qinghua²,Liu Xiayan³,Chen Ke³,Chen Xinyi³,Han Junyong²,Liao Zhijun¹

Affiliation:

1. Fujian Medical University

2. Fujian Academy of Medical Sciences

3. Fujian University of Traditional Chinese Medicine

Abstract

Mitochondrial ribosomal protein L27 (MRPL27) is a member of mitochondrial ribosomal proteins (MRPs). However, the biological function of MRPL27 in hepatocellular carcinoma (LIHC) is still unclear. Use UALCAN, TIMER, TISIDB, Kaplan Meier, and GEPIA database systems to analyze the expression, prognostic value, and relationship between MRPL27 and immune infiltration in LIHC. The expression and clinical significance of MRPL27 in LIHC patients were validated using tissue microarray. Conduct cell function experiments to detect the effects of overexpression and knockdown of MRPL27 on the proliferation, migration, and invasion of Huh7 cells. The tissue microarray results confirmed that MRPL27 expression is upregulated in LIHC, and high MRPL27 expression is associated with poorer prognosis. The expression of MRPL27 is significantly correlated with the infiltration levels of immune modulators, chemokines, and various immune cells. In addition, MRPL27 affects the proliferation, migration, and invasion of LIHC cells. These data indicate that MRPL27 is a new prognostic biomarker for LIHC and is associated with immune infiltration in LIHC.

Publisher

Springer Science and Business Media LLC

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