Causal associations between gut microbiota and three prostate diseases: A bidirectional two-sample Mendelian randomization study

Author:

Liu Xiaoyang1,Yang Luchen1,Peng Zhufeng1,Song Pan1,Liu Zhenghuan1,Zhou Jing1,Ma Kai1,Yu Yunfei1,Dong Qiang1

Affiliation:

1. Department of Urology, Institute of Urology, West China Hospital, Sichuan University

Abstract

Abstract Background: According to observational research and clinical trials, the gut microbiota is associated with prostate disorders. However, the causal association between gut microbiota and prostate disorders is yet uncertain. Methods: We first identified groups of gut microbiota based on knowledge on the phylum, class, order, family, and genus levels, and acquired prostate diseases statistics from the FINNGEN study and PRACTICAL consortium. Next, two-sample mendelian randomization was used to investigate the potential associations between three prevalent prostate diseases and gut microbiota. In addition, we performed a reverse MR analysis and Benjamini-Hochberg (BH) test for further research. Results: We investigated the connection between 196 gut microbes and three prevalent prostate diseases and discovered 42 nominally significant relationships and 2 strong causative connections. The BH corrected analysis indicated that the risk of prostatitis is positively correlated with the presence of the Order Gastranaerophilales, while the risk of prostate cancer is inversely correlated with the presence of the Class Alphaproteobacteria. Conclusions: Our MR analysis revealed that the gut microbiota was causally associated with prostate diseases and the results may serve as diagnostic biomarkers and therapeutic targets for prostate diseases.

Publisher

Research Square Platform LLC

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