The Joint Impact of Depression Status and TyG Index on Overweight Incidence: A cross-sectional Study based on CHARLS in 2015

Abstract

Background Depressive status and triglyceride-glucose index (TyG) have both been reported to be associated with the development of overweight. However, there is a paucity of literature exploring the joint effect of TyG changes and depressive status on the occurrence of overweight. The purpose of this study was to investigate the relationship between depression status and TyG index with the incidence of hypertension, and to analyze the combined effect of depression status and TyG index on the incidence of overweight. Methods We conducted a prospective cohort study using data from the China Health and Retirement Longitudinal Study (CHARLS), a nationwide population-based study. Occurrence of overweight was determined among eligible respondents to CHARLS in 2015 on the basis of 10-item scores on the Center for Epidemiologic Studies Depression Scale (CES-D-10). logistic model was used to calculate the relationship between depressive status and TyG index and the incidence of overweight. Logistic regression model was used for subgroup analysis of smoking variables. In addition, after propensity score matching, the logistic model was re-applied to calculate the relationship between depression status and TyG index and the incidence of overweight. Finally, the multiplicative interaction between depression status and TyG index was calculated. Results In the results, the risk of overweight in those with depression was 79% of that in those without depression (OR = 0.79, 95% CI: (0.66,0.95)),The risk of overweight with a TyG index > 5 was 302% of that with a TyG index of 4–5 (OR = 3.02, 95% CI: (2.45,3.73))。There was a significant interaction between depression status and TyG index, except for the presence of a depressive state plus a TyG index of 4–5 this combination (OR = 0.69, 95% CI: (0.55,0.86)) had a negative combined effect on the development of overweight, the other factors showed a positive combined effect on overweight, and the combined effect of depression and TyG index > 5 (OR = 3.6, 95%CI: (2.27,5.73)) was the largest. Conclusion Our research findings further confirm that the TyG index and depression have a significant impact on the occurrence of overweight. To reduce the high medical expenses caused by obesity and overweight, We need to pay more attention to psychological status and insulin resistance status.