Intracranial volumetric evaluation in postnatally repaired myelomeningocele infants

Author:

Hashimoto Hiroaki1,Irizato Naoki1,Takemoto Osamu1,Chiba Yasuyoshi1

Affiliation:

1. Osaka Women’s and Children’s Hospital

Abstract

Abstract

Introduction Most myelomeningocele (MMC) cases exhibit ventriculomegaly or hydrocephalus, yet a comprehensive volumetric assessment of MMC intracranial structures is lacking. This study aims to provide baseline data on intracranial structural volume immediately after birth in postnatally repaired MMC infants. Methods In this retrospective single-center study, we analyzed 52 MMC infants undergoing postnatal closure, utilizing head computer tomography scans at birth for volumetric assessment. Intracranial volume (ICV), lateral ventricles volume (LVV), choroid plexus volume (CPV), and posterior cranial fossa volume (PCFV) were measured. Comparative analysis with healthy controls (eight infants at 0 months) employed the Wilcoxon rank-sum test. Receiver operating characteristic (ROC) analysis discriminated cases with and without ventriculoperitoneal shunt (VPS). Results MMC infants exhibited significant differences compared to healthy cases in LVV (33.18 mL vs. 2.05 mL, p < 0.001), CPV (0.67 mL vs. 0.25 mL, p = 0.005), and PCFV (21.35 mL vs. 39.50 mL, p < 0.001), but not in ICV (407.50 mL vs. 418.15 mL, p = 0.25). Thirty-seven cases (71.15%) underwent VPS. ROC analysis revealed an LVV cut-off value of 6.74 mL for discriminating cases with and without VPS. Conclusion Postnatally repaired MMC infants showed significantly larger LVV and CPV, and smaller PCFV compared to healthy infants, providing crucial baseline data for volumetric evaluation. These findings enhance our understanding of intracranial volumetric changes in MMC, facilitating more objective assessments of MMC cases.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3