Abstract
Background
Previous studies have shown that the albumin-to-creatinine ratio (ACR) is associated with the prognosis of patients with liposarcoma. However, the role of ACR in other tumors is unknown. Our aim was to evaluate the relationship between ACR and the prognosis of common tumors.
Methods
We used data from the Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) between 2013 and 2022 to identify Young and middle-aged patients (< 65). Spearman method was used to determine the correlation between albumin, creatinine, ACR and age. In a model adjusted for covariates, the prognostic relationship between ACR and common tumors was investigated. Subgroup analysis was performed in different tumors. Finally carried out C indices analysis to observe the value of ACR in cancer patient outcomes.
Results
In COX regression analysis of ACR and prognosis of tumor patients, whether ACR is used as a continuous variable (per 10 unit increase) or quartile, the greater the ACR value, the better the prognosis of the study population. The same results were found for different cancer species. In the C-index analysis, the prognosis of patients evaluated by ACR and tumor stage was significantly higher than that of patients evaluated by tumor stage alone.
Conclusion
A high ACR ratio is associated with a better prognosis in patients with common tumors, and is significantly better in evaluating cancer outcomes in combination with tumor stage than in evaluating tumor stage alone.