Insilco analysis of an interaction between an endogenous peptide fragment of NUR77 receptor from human cells and USAG1 protein - may induce teeth regeneration

Abstract

Abstract BMP-7 and WNT signaling are responsible for the development of teeth. USAG-1 (uterine sensitization associated gene-1) inhibits bone morphogenetic protein-7 protein (BMP-7) as well as WNT receptors leading to suppression of tooth development and growth. The inhibition of USAG-1 using an antibody has been shown to induce tooth regeneration in mice. Hence, USAG-1 is a drug target that is promising enough for teeth generation. In this paper, for the first time, it has been proposed that an endogenous peptide that is part of the NUR-77 receptor in human cells may inhibit USAG-1 protein to induce tooth regeneration when injected locally. The peptide FSRSLHSL of the NUR-77 receptor interacts with the usag-1 protein through enough hydrogen bonds as shown by the docking studies. BCL-2 expression determines the mineralogical composition of enamel crystals of tooth structure. The peptide FSRSLHSL doesn’t convert the character of BCL-2 to proapoptotic although the addition of an extra amino acid “L” to derive FSRSLHSLL leads to an orthogonal behavior.