Assessment of an instrument scale measuring the knowledge of antiretroviral therapy among HIV cases

Author:

Xu Di1,Shi Yuhua2,Pan Ling1,Duan Qiongli3,Huang Nengmei3,Liu Pengcheng1,Han Jing1,Liu Zhongfu1,Li Jian1,Liu Hongjie4

Affiliation:

1. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention

2. Yunnan Center for Disease Control and Prevention

3. Center for Disease Control and Prevention in Honghe Hani and Yi Autonomous Prefecture

4. University of Maryland

Abstract

Abstract Background: Antiretroviral therapy (ART) is currently the most effective measure to treat people were living with human immunodeficiency virus (PLHs) and reduce HIV transmission. While there are many factors that reduce adherence to ART, PLHs’ knowledge about ART may determine the level of adherence. It is necessary to design and assess an instrument scale that measures the knowledge of antiretroviral therapy among HIV cases. Method: A cross-sectional study was conducted among HIV cases in Honghe Hani and Yi Autonomous Prefecture, China. Both exploratory and confirmatory factor analyses were used to examine the latent factors of antiretroviral therapy knowledge scale. Internal consistency was assessed separately for the scale and its dimensions by estimating Cronbach’s alphas, split-half reliability and Spearman's correlation coefficient. ANOVAs were used to compare the scores of different dimensions with sociodemographic characteristics. Results: Exploratory and confirmatory factor analyses were performed in two independent samples: a development sample (N = 205) and a validation sample (N = 205). According to factor loadings, four factors were extracted. They had high internal consistency reliability (Cronbach’s alpha: 0.70 - 0.95) and good construct validity (standardized factor loading range: 0.46–0.86) in the scale. Goodness of fit indices indicated that a four-factor solution fit the data at an accepted level (χ2/degree ratio=1.980, RMSEA=0.069, GFI=0.909, CFI=0.957, NFI=0.917, TLI=0.944). ANOVAs indicated that the score was higher among HIV cases who were Han, had spouses/partners, were non-famers or migrant workers, initiated ART, and had a high school or above education. Conclusion: The psychometric assessment indicated that this ART knowledge scale had accepted internal consistency and discriminant construct validity. It can be used to assess the knowledge of antiretroviral therapy for HIV cases.

Publisher

Research Square Platform LLC

Reference32 articles.

1. 1. UNAIDS. Global HIV & AIDS statistics — 2020 fact sheet [Internet]. Available at: https://www.unaids.org/en/resources/fact-sheet.

2. 2. Travasso C. New cases of HIV in India could fall by 38% with early ART and better retention, finds study. BMJ 2015; 351: h5684.

3. 3. Bispo S, Chikhungu L, Rollins N, et al. Postnatal HIV transmission in breastfed infants of HIV-infected women on ART: a systematic review and meta-analysis. J Int AIDS Soc 2017; 20(1): 21251.

4. 4. Stone L. The perfect PARTNER: no HIV transmission with ART. Nat Rev Urol 2019; 16(7): 387.

5. 5. UNAIDS. 90-90-90 An ambitious treatment target to help end the AIDS epidemic [Internet]. Available at: https://pancap.org/pc/pcc/media/pancap_document/90-90-90_Targets.pdf.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3