Machine Learning Uncovers CCM Isoforms as Transcription Factors

Author:

Zhang Jun1ORCID,Croft Jacob2ORCID,Gao Liyuan3,Sheng Victor3

Affiliation:

1. jun.zhang2000@gmail.com

2. Texas Tech University Health Science Center El Paso

3. Texas Tech University

Abstract

Abstract This study investigates the TF potential of CCM gene isoforms that undergo alternative splicing and nucleocytoplasmic shuttling. Experiments showed that CCMs shuttle with progesterone receptors, which act as both cell signaling components and TFs, raises the possibility of CCMs as TFs. The study challenges existing knowledge with a Biased-SVM model to indicate that numerous CCM isoforms function as TFs.

Publisher

Research Square Platform LLC

Reference10 articles.

1. Alternatively spliced isoforms reveal a novel type of PTB domain in CCM2 protein;Jiang X;Sci Rep,2019

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3. Zhang, J., Basu, S., Rigamonti, D., Dietz, H.C. & Clatterbuck, R.E. krit1 modulates beta1-integrin-mediated endothelial cell proliferation. Neurosurgery 63, 571-8; discussion 578 (2008).

4. Zhang, J., Rigamonti, D., Dietz, H.C. & Clatterbuck, R.E. Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations. Neurosurgery 60, 353-9; discussion 359 (2007).

5. CCM1-ICAP-1 complex controls beta1 integrin-dependent endothelial contractility and fibronectin remodeling;Faurobert E;J Cell Biol,2013

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