ncRNAs-mediated high expression of CDCA7L favors the prognosis of uveal melanoma and is associated with an immune checkpoint PD1

Abstract

Abstract Uveal melanoma (UVM) is the most common primary malignant tumor in adults and seriously threatens patients' eyesight and life. More and more evidence shows that the CDCA7L gene plays a crucial role in the occurrence and development of several human cancers. However, the specific part and mechanism of CDCA7L in UVM have not been completely determined. In this study, we first analyzed the expression and prognosis of CDCA7L by using the Cancer Genome Map (TCGA) data and Genotype-Tissue Expression (GTEx). We found that the expression of CDCA7L was beneficial to the prognosis of UVM. Subsequently, non-coding RNA related to CDCA7L was identified through computer analyses, including expression analysis, correlation analysis, and survival analysis. Finally, LRRC75A-AS1 and SNHG1/hsa-miR-199a-5p/ CDCA7L axes were identified as the most potential upstream ncRNA-related pathways of UVM CDCA7L. In addition, the level of CDCA7L was negatively correlated with the expression of PD1 in the immune checkpoint. Our findings clarify that the up-regulation of CDCA7L mediated by ncRNAs in UVM benefits tumor prognosis and is related to immune checkpoint PD1.