An updated two-sample Mendelian randomization study: COVID-19 and pre-eclampsia superimposed on chronic hypertension

Abstract

Abstract Objective: To investigate the association between COVID-19 and pre-eclampsia superimposed on chronic hypertension (SPE). Design: Two-sample Mendelian randomization study. Setting: COVID-19 Host Genetics Initiative (version R7) and FinnGen consortium (version R9). Patients: A total of 222978 cases and 6284909 controls are derived from three different COVID phenotypes of the COVID-19 Host Genetics Initiative, 154 cases, and 194266 controls with pre-eclampsia superimposed on chronic hypertension (SPE) from FinnGen. Intervention (s): None. Mains Outcome Measure: SPE. Result(s): Genetic predisposition to three different COVID phenotypes of the COVID-19 was associated with an increased risk of SPE, their IVW ORs (95% CIs) and P-values are 1.39 (1.00-1.92) and 0.04, 1.88 (1.17-3.02) and 0.008, 6.41 (1.27-32.22) and 0.02, respectively. Conclusion (s): This study based on genetic data suggests the causal potential of the association between COVID-19 and SPE.