Association between serum uric acid and age and the prevalence of hyperuricemia in patients with psychiatric disorders: A cross-section study

Abstract

Abstract Objective：The present study aimed to evaluate the incidence of hyperuricemia (HUA) and the relationship between the Serum uric acid (SUA) and age in hospitalized patients with psychiatric disorders. Methods：This is a cross-sectional evaluation of a cohort of 1761 patients with psychopath of hospitalized (665 males and 1096 females). In addition, based on age, the participants are stratified into three groups. The authors used Kruskal-Wallis tests, chi-square tests，and multiple linear logistic regression to verify the SUA level and age among hospitalized psychopath. Results：Overall, the estimated prevalence of HUA was 35.4%. The prevalence of HUA was significantly higher in individuals with 17years and under, as compared to those with 45 years and above (40.5% vs. 24.9%, respectively, P < 0.001). No adjusting，the 17years and under was associated with HUA (OR 2.06; 95% CI 1.57-2.71). Further adjusted for potential confounders, the 17years and under was still significantly associated with HUA (adjusted OR 6.85; 95% CI 4.79-9.80). Moreover, the association between the age and HUA was stronger in men. SUA is not proportional to age，Body Mass Index, Triglyceride，Total Cholesterol , Blood pressure. Conclusion：Smooth curve fitting indicated the existence of a non-linear relationship between SUA and age. Age is a protective factor for SUA in hospitalized patients with psychiatric disorders.