Affiliation:
1. General Practice Medical Center, Sichuan University
2. Shandong Daizhuang Hospital
Abstract
Abstract
Background
In recent years, an increasing number of studies have confirmed that air pollution mixtures can lead to abnormal levels of lipid proteins in the body. With the continuous deepening of research, the specific effects of different components in air pollution mixtures on human health have gradually begun to be explored. Nitrogen dioxide (NO2), as an essential component of air pollutants, hurts human health. Normal levels of high-density lipoprotein (HDL) play a crucial role in preventing cardiovascular diseases. However, the effect of environmental NO2 on HDL levels has yet to be further studied. Our study aims to explore the potential association between environmental NO2 exposure and HDL levels in middle-aged and elderly populations aged 45 and above in China.
Methods
Our research subjects are the third-wave China Health and Retirement Longitudinal Study (CHARLS) participants. This cross-sectional study analyzed the personal data of 12519 participants aged 45 and above with venous blood samples. The participants' high-quality and high-resolution NO2 exposure concentration data were obtained from the Chinese Air Pollutants (CHAP) dataset, and the HDL levels were obtained from the analysis results of venous blood samples. Multiple linear regression analysis, supplemented by subgroup analysis, was used to explore the correlation between NO2 exposure concentration and HDL levels.
Results
This cross-sectional study found a negative correlation between long-term exposure to air NO2 and HDL levels. The observed correlation between air NO2 and HDL levels indicates that middle-aged and older adults living in areas with high NO2 concentrations exhibit a decrease in HDL levels (Beta: -0.132; 95% CI: (-0.153, -0.111); P < 0.0001). This association still exists after considering various potential confounding factors (Beta=-0.103, 95% CI: -0.124, -0.083, p < 0.0001).
Conclusions
Our research results show a significant negative correlation between long-term exposure to high concentrations of NO2 and HDL levels in the middle-aged and elderly population in China.
Publisher
Research Square Platform LLC
Reference44 articles.
1. WHO Guidelines Approved by the Guidelines Review Committee. In: WHO global air quality guidelines: Particulate matter (PM(25) and PM(10)), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. edn. Geneva: World Health Organization © World Health Organization 2021.; 2021.
2. Ambient Air Pollution Is Associated With HDL (High-Density Lipoprotein) Dysfunction in Healthy Adults;Li JP;Arterioscl Throm Vas,2019
3. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019;Murray CJL;Lancet,2020
4. Antioxidant properties of HDL;Soran H;Front Pharmacol,2015
5. Dysfunctional HDL and atherosclerotic cardiovascular disease;Rosenson RS;Nat Rev Cardiol,2016